Further illuminating matters, function and therapeutic efficacy of MSCs are hugely controlled from the encompassing niche/microenvironment (Zhu et al., 2016; Mehrbani Azar et al., 2018; Tejero et al., 2019; Gilchrist et al., 2021), and reports on skeletal degenerative and autoimmune ailments have highlighted the essence of cell-host interaction
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